Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-
Quassin
CAS: 76-78-8
Molecular Formula: C22H28O6
Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- - Names and Identifiers
Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- - Physico-chemical Properties
| Molecular Formula | C22H28O6 |
| Molar Mass | 388.45 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Melting Point | 222° |
| Boling Point | 586.3±50.0 °C(Predicted) |
| Specific Rotation(α) | D20 +34.5° (c = 5.09 in CHCl3) |
| Solubility | Soluble in DMSO |
| Appearance | Powder |
| Color | White to Off-White |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| MDL | MFCD00273126 |
| In vitro study | Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. |
Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Quassin (nigakil strain D) is a bioactive triterpene extracted from the stem bark extract of quasamara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin has reversible antifertility, antiestrogenic and antiplasmodium activity. |
| Target | IC50: 0.15 μM ( P. falciparum ) |
| Animal Model: | 35 females albino rats (150-170 g) |
| Dosage: | 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg |
| Administration: | Oral administration; daily; for 60 days |
| Result: | There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |
| Use | Quassin is a natural occurring extract from quassia trees and is used in traditional chinese medicine for it. Quassin have also been used as an additive in soft drinks. |
Last Update：2024-04-09 20:52:54
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Product Name: Quassin Visit Supplier Webpage Request for quotationCAS: 76-78-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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